These notes are based on this youtube video, double-checked that the information is correct from the book below.
Direct (bind directly
to acetylcholine receptors and act like acetylcholine)
Be My Parasympathetic
Choline
- Bethanechol (used for Bowel and Bladder emptying in atonic bladders because they increase motility)
- Methacholine (used in asthma diagnosis)
- Pilocarpine (increases sweat, tears and salivation and increases aqueous humor outflow and miosis, so used in glaucoma and dry mouth diseases)
- Carbachol (increases aqueous humor outflow and miosis, so used in glaucoma)
Indirect (act by
inhibiting acetylcholinesterase and thereby prolonging effect of acetylcholine)
End in ‘stigmine’
Reversible cholinesterase inhibitors
- Neostigmine/pyridostigmine
- Physostigmine (only one that crosses CNS and can be used in toxicity of atropine)
- Edrophonium (in diagnosis of myasthenia gravis because it is short acting)
Irreversible cholinesterase inhibitors
- Echothiphate (glaucoma)
Reference:
Mycek, M.J.; Harvey, R.A.; Champe, P.C. (2000). Lippincott's Illustrated Reviews - Pharmacology 2nd ed.
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